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| GeneticLevel | REQUIRED. Describes the level of analysis |`Genetic`, `Genomic`, `Epigenomic`, `Transcriptomic`, `Metabolomic`, or `Proteomic`|
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| AnalyticalApproach | OPTIONAL. Methodology or methodologies used to analyse the GeneticLevel | String or list of strings. Each Value must be taken from the [database of Genotypes and Phenotypes (dbGaP)][gapsolr] under /Study/Molecular Data Type, for instance `SNP Genotypes (Array)` or `Methylation (CpG)`|
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| SampleOrigin | REQUIRED. Describes from which tissue the genetic information was extracted |`blood`, `saliva`, `brain`, `csf`, `breast milk`, `bile`, `amniotic fluid`, `other biospecimen`|
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| TissueOrigin | OPTIONAL. Describes the type of tissue analyzed for SampleOrigin `brain`|`gray matter`, `white matter`, `csf`, `meninges`, `macrovascular` or `microvascular`|
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| BrainLocation | OPTIONAL. Refers to the location in space of the TissueOrigin |`MNI coordinate` or a `label` taken from the [Allen Brain Atlas][allen] possibly `layer` to refer to layer-specific gene expression, which can also tie up with laminar fMRI |
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| CellType | OPTIONAL. Describes the type of cell analyzed | Value should come from the [cell ontology][ontology]|
| GeneticLevel | REQUIRED. Describes the level of analysis |`Genetic`, `Genomic`, `Epigenomic`, `Transcriptomic`, `Metabolomic`, or `Proteomic`|
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| AnalyticalApproach | OPTIONAL. Methodology or methodologies used to analyse the GeneticLevel | String or list of strings. Each Value must be taken from the [database of Genotypes and Phenotypes (dbGaP)][gapsolr] under /Study/Molecular Data Type, for instance `SNP Genotypes (Array)` or `Methylation (CpG)`|
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| SampleOrigin | REQUIRED. Describes from which tissue the genetic information was extracted |`blood`, `saliva`, `brain`, `csf`, `breast milk`, `bile`, `amniotic fluid`, `other biospecimen`|
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| TissueOrigin | OPTIONAL. Describes the type of tissue analyzed for SampleOrigin `brain`|`gray matter`, `white matter`, `csf`, `meninges`, `macrovascular` or `microvascular`|
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+
| BrainLocation | OPTIONAL. Refers to the location in space of the TissueOrigin |`MNI coordinate` or a `label` taken from the [Allen Brain Atlas][allen] possibly `layer` to refer to layer-specific gene expression, which can also tie up with laminar fMRI |
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| CellType | OPTIONAL. Describes the type of cell analyzed | Value should come from the [cell ontology][ontology]|
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To ensure dataset description consistency, we recommend following [Multi-omics approaches to disease](https://genomebiology.biomedcentral.com/articles/10.1186/s13059-017-1215-1) by Hasin et al. 2017 to determine the `GeneticLevel:`
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-`Genetic`: data report on a single genetic location (typically directly in the `participants.tsv` file)
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